As a crystalline compound, it is an intermediate of ketoconazole. It is harmful to ingestion and can irritate the eyes, respiratory system and skin, so take precautions during use.
Category: Intermediates/Pharmaceutical intermediates
CAS NO: 67914-60-7
EC NO: 267-744-8
Molecular Formula: C12H16N2O2
Molecular Weight: 220.2676
Melting point : 180-185 °C (lit.)
Boiling point : 361.21°C (rough estimate)
Density : 1.1115 (rough estimate)
Refractive index : 1.6000 (estimate)
Storage conditions : -20°C Freezer
Color: White to slightly pink or beige
Water solubility : 4.3 g/L (20 oC)
4-(4-Acetyl-1-piperaino)phenol; Tetraethoxy C methyl propane;
For the synthesis of the drug ketoconazole, itraconazole.
The piperazine hexahydrate can be first condensed with p-nitrochlorobenzene to form 1-(4-nitrophenyl)piperazine. It is then reacted with acetic anhydride to give 1-acetyl-4-(4-nitrophenyl)piperazine which is reduced, diazotized and hydrolyzed by the nitro group.
Store in a sealed container and store in a cool, dry place. Store away from oxidizing agents.